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HER2 monotherapy (trastuzumab or lapatinib or pertuzumab) versus dual anti-HER2 therapy (trastuzumab plus lapatinib or trastuzumab plus pertuzumab) was performed.
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Now, many patients with early-stage cancers can choose breast-conserving treatment, or lumpectomy followed by radiation, with or without chemotherapy.
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If the participant has had an open breast biopsy within the last two months or there is a clinical indication for an open breast biopsy, pathology results must be reviewed.
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Thus, it will be necessary to examine network effects across variants in all pathway genes.
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Although there were more endometrial abnormalities in the tamoxifen-alone group, the difference was not large enough to be statistically significant.
The cancer at this stage is considered to be chronic and incurable, and the usefulness of treatments is limited.
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While 331 in the drug group died of breast cancer during follow up, 397 in the group that stopped died.
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An additional possible reason for the disparity between in vivo and epidemiological evidence, according to the researchers, is that the SSRI reduction of the plasma concentration of the tamoxifen active metabolites may not be sufficient to reduce its effectiveness.
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Information about breast cancer risk, prevention, and participation in clinical trials should be developed and tailored in ways that are culturally relevant and sensitive to the needs of women from a range of racial, ethnic, cultural, and socioeconomic backgrounds.
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