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Against the hypothesis that modafinil exerts its effects by acting as a DRI, (which deplete dopamine) fail to block the effects of modafinil in animals.

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It was first synthesized by Eli Lilly and Company in 1968.

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In hindsight, I believe that the SSRIs (fluoxetine and sertraline) and the TCAs (particularly clomipramine) helped more than I realized at first.

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Response analyses (rates of individual response) are often performed to illustrate the clinical relevance of results.

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Table III summarizes published placebo-controlled studies of drugs for motor hyperactivity and inattention.

The minimum recommended interval between dose increases is one week, and only if the previous dose has been well tolerated.

Assessment was at entry to the study and subsequently at 4-weekly intervals.

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Additional eligible studies were sought via a search of the reference lists from primary articles and relevant reviews.

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