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It was first synthesized by Eli Lilly and Company in 1968.
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Positron emission tomography (PET) demonstrates that methylphenidate decreases regional cerebral blood flow in the doroslateral prefrontal cortex and posterior parietal cortex while improving performance of a spatial working memory task.
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In hindsight, I believe that the SSRIs (fluoxetine and sertraline) and the TCAs (particularly clomipramine) helped more than I realized at first.
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Response analyses (rates of individual response) are often performed to illustrate the clinical relevance of results.
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The minimum recommended interval between dose increases is one week, and only if the previous dose has been well tolerated.
Assessment was at entry to the study and subsequently at 4-weekly intervals.
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Additional eligible studies were sought via a search of the reference lists from primary articles and relevant reviews.
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