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Oral absorption is not reduced in small bowel Crohn's disease but absorption is highly variable and is also dose dependent, with bioavailability decreasing by a mean 13.

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The care is essentially similar to that for any patient who has had severe adverse effects from chemotherapy.

Males should continue to use birth control for at least 3 months after the end of treatment.

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Lab tests will be performed to verify the pregnancy, check the blood count and determine your Rh factor.

Among 31 patients with psoriasis on methotrexate therapy, liver biopsies showed mild to moderate fatty change and none had progression of fibrosis, but abnormalities that did occur correlated with lower red cell folate and higher methotrexate levels).

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Although we believe the occurrence of this complication in one of our patients was probably due to chance, further study of patients with Crohn's disease treated with methotrexate will be needed to exclude a causal relation.

We conducted a randomized comparison of methotrexate with cyclosporine as monotherapy for chronic plaque psoriasis, evaluating side effects, clinical effectiveness, time to and duration of remission, and quality of life.

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When administered postoperatively as the sole agent after ablation of the primary tumor, it increased survival to 40%, and in combination with other agents (pre- and postoperative therapy), it increased survival to 65% to 75%.

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In about 1 percent of patients, infusion reactions can be severe and can mimic a severe allergic reaction or lead to convulsions.

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Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate.

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My Doctors took me off of the methotrexate today and they ordered a battery of test to find out if there is any damage to the hippocampus region of my brain.

Our experience as well as that of other investigators underlines the importance of avoiding reduced doses of chemotherapy if maximal benefit is to be achieved.

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The Short Form-12 questionnaire will be summarized for all components.

If methotrexate therapy is reinstituted, it should be carried out with caution, with adequate consideration of further need for the drug and with increased alertness as to possible recurrence of toxicity.

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Solomon SD, Wittes J, Finn PV, et al, for the Cross Trial Safety Assessment Group.

This rapid response is in contrast to the relatively slow onset (three to six months) of therapeutic effect with the antimetabolites azathioprine and mercaptopurine.

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When the drug is withdrawn, as has been done in studies, all signs of improvement disappear and a flare-up of symptoms occurs within a few weeks.

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